Background:Doxycycline is a broad spectrum antibiotic of tetracycline, a tetracycline antibiotic that inhibits bacterial growth and spread. Doxycycline is known to cause gastrointestinal symptoms such as vomiting and diarrhea when administered during hospitalization or after discontinuation of treatment, resulting in a lack of treatment availability. There is a need to improve the efficacy of doxycycline in treating bacterial infections. There is limited information on the use of doxycycline for treating infections caused by susceptible bacteria. There are no data on the effect of doxycycline on the growth of susceptible isolates ofPseudomonas aeruginosa.

Doxycycline is used to treat infections caused by Gram-positive and Gram-negative bacteria. Gram-positive bacteria are Gram-negative organisms that are susceptible to doxycycline. Gram-negative bacteria, such asStaphylococcusspp.,P. aeruginosaspp., andspp., are generally more susceptible to doxycycline than Gram-positive bacteria, but some strains of gram-negative bacteria may have greater susceptibility to the drug.

Use:Gram-positive and gram-negative bacteria may be more susceptible to doxycycline than Gram-negative bacteria. The use of doxycycline for treatinginfections is less common, however, as resistance to doxycycline is greater than resistance to other tetracyclines. The use of doxycycline in treatinginfections is also less common than in the treatment ofEnterobacteriaceaeinfections. Other types of organisms, including thespp. andspp., may also have resistance to doxycycline. This is especially true ofthat may be resistant to doxycycline.infections is less common than in treatingThese bacteria may be more susceptible to doxycycline than gram-negative bacteria, and are more resistant to the drug.infections is also less common than in treating

Tetracyclinesare drugs that inhibit the growth and spread of microorganisms. Tetracyclines are drugs that inhibit the growth and spread of microorganisms. Tetracyclines can kill or slow the growth of anaerobic bacteria, includingC. difficile

Antibioticsare a class of drugs that inhibit the growth and spread of microorganisms. Antibiotics are drugs that inhibit bacterial growth and spread by inhibiting bacterial protein synthesis. They are used to treat infections caused by gram-positive and gram-negative bacteria. They are used to treat infections caused byThey may be used to treatinfections such as those caused byPseudomonas

The most common use of antibiotics is to treat infections caused by bacteria. However, it is not uncommon to treat infections caused bysuch asE. coliKlebsiellaThe use of antibiotics for treating infections caused byis less common than the use of antibiotics for treating

Tetracycline is an antibiotic that inhibits bacterial growth and spread by binding to bacterial protein-DNA and interfering with the ability of bacteria to spread within the host. Tetracycline is used to treat infections caused by Gram-positive and Gram-negative bacteria.

Common Name: Tetracycline HCl; Achromycin V

CAS Number: 64-75-5

Molecular Weight: 480.90

Chemical Formula: C22H24N2O8 • HCl

Solubility: Water

Storage Temperature: Room Temperature

Tetracycline hydrochloride is a hydrochloride salt form of the antibiotic tetracycline. This polyketide antibiotic binds to both the 30S and 50S ribosomal subunits, thus inhibiting proper protein synthesis. Although it is capable of binding to both subunits, the binding at the 30S subunit is more pronounced than that at the 50S. Clinically, tetracycline is used as a broad spectrum antibiotic for a variety of Gram-positive and Gram-negative bacterial infections. Conditions which may indicate for tetracycline administration include upper respiratory infection, typhus fever and rikkettsialpox. It can also be administered to treat severe cases of acne. Tetracycline has played a prominent research role in studies of the efficacy of local antibiotic application in cases of dental trauma. Owing to the fluorescent properties of tetracycline and its ability to bind to bone tissue, this antibiotic is also regularly used in bone histomorphometry studies.

Research or further manufacturing use only, not for food or drug use.

This drug is available in the following doses as an oral suspension.

Dosage Information

$50/ml Single dose. The recommended starting dose is 50 mg per day. Children under 12 years of age may be administered the dose as a single 5 ml oral suspension once daily. In case of accidental overdosage, the dose may be adjusted by the physician to a maximum recommended daily dose of 100 mg per day.

Dose by SUSPICIOS/PERCIPIOS

$100/ml Two-dose. The second dose is administered every 12 hours as a two-dose preparation. The single dose preparation is administered once daily.

Dose by PHARMACEUTICAL SUSPENSION

$250/ml Three-dose. The three-dose preparation is administered once daily.

Dose by PHARMACOKINE SUSPENSION

$500/day Single dose.

Dose by PHARMATIN SUSPENSION

The medication should be administered by the physician in a manner which is not interfering with the patient's ability to absorb the drug. In case of accidental overdosage, the dose may be adjusted by the physician to a maximum of 100 mg per day. In some cases, the physician may recommend that the physician administer additional dosage to the patient's body weight in order to compensate for the increase in body weight.

Overdoses are very unlikely to be fatal, but should be considered in patients with significant hepatic disease, severe renal impairment or if applicable, the dose may be adjusted according to the response of the patient. Doses in the therapeutic range are not recommended for patients with severe hepatic disease. In such cases, the physician may administer doses of two or three times the maximum daily dose to the patient's body weight, as determined by the physician.

If the dose is administered to the patient's body weight in a manner which is not providing adequate absorption of tetracycline, it is recommended that the physician administer additional dosage to the patient's body weight in order to compensate for the increase in body weight. In such cases, the physician may advise the patient to take a double dose of tetracycline to compensate for the increase in body weight.

Tetracycline Hydrochloride Injection

Manufacturer Information

Tetracycline Hydrochloride Injection USP is a polyvalent serum antibiotic.

While adverse reactions to tetracycline are uncommon, some patients who take the drug may experience side effects, including headaches, gastrointestinal problems (stomach cramps, diarrhea), and dermal photosensitivity (increased skin sensitivity to sunlight). Tetracycline and other antibiotic medications have been known to cause yeast infections, so be on the lookout for symptoms like vaginal discharge, itching, or discomfort.

This is not a complete list of adverse effects – though these are among the most common. Seek medical attention right away if you experience symptoms such as abdominal pain, loss of appetite, nausea and vomiting, visual changes, or yellowing skin while taking tetracycline.

As with all prescription medication, be sure to inform the prescribing doctor about any medical conditions you have been previously diagnosed with, as well as any medication/ supplements you are currently taking before starting treatment with tetracycline. Tetracycline can interact with other forms of medication and substances, causing potentially serious side effects or life-threatening allergic reactions. Drug interactions can occur with blood thinners such as warfarin, certain retinoids, penicillin, and proton pump inhibitors among others.

Antacids and supplements containing calcium and magnesium can reduce the amount of tetracycline that your body absorbs, so be sure to take tetracycline 1–2 hours before or 1–2 hours after taking antacids or supplements.

Using tetracycline can cause your skin to become sensitive to sunlight or ultraviolet light, so try to avoid unnecessary exposure to the sun or UV rays (tanning beds) and do your best to wear protective clothing, sunglasses, or sunscreen that is SPF 15 or higher. Call your doctor if you notice redness, swelling, or blistering as a result of sun exposure while on tetracycline.

Oral contraceptives (birth control pills) with estrogen can lose effectiveness when combined with tetracycline, so unplanned pregnancy can occur.

In addition, let your doctor know if you are breastfeeding, pregnant or plan on becoming pregnant before starting treatment with this medication.

otschep.com/otschep/bio/tetracycline/YE.jpg'#tetracycline-YE'Ooxf@wiley.

Uses of Doxycycline+Lactic Acid Bacillus

The combination of Doxycycline+ Lactic Acid Bacillus is used in the treatment of various bacterial infections such as respiratory tract infections, urinary tract infections, middle ear infections, intra-abdominal infections, gastrointestinal infections, bone and joint infections, and the conditions of infections in the skin, joints, muscle, joints, and abdomen.

Therapeutic Category

Doxycycline : Antibiotics

Lactic Acid Bacillus : Probiotics

How Doxycycline+Lactic Acid Bacillus works

Doxycycline is an antibiotic which stops bacterial growth by preventing the synthesis of essential proteins required by the bacteria to carry out vital functions. Lactic Acid Bacillus capsules are used in the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, middle ear infections, intra-abdominal infections, gastrointestinal infections, bone and joint infections, and the conditions of infections in the skin, joints, and abdomen. You are advised to choose a probiotic during the course of treatment, as it can be purchased from a pharmacist before the entire course of treatment is recommended.

Usage Detail

• Ridgelles: 50 mg+100 mg capsule

Can I take the liquid capsule with food?

Do not take doxycycline+lactic acid Bacillus if you are allergic to Doxycycline, Lactic Acid Bacillus, or any of its ingredients. Let Health Professional Classes, Generalveders Only,riganue know the correct dosage and duration of treatment for their patients.

How do I take Doxycycline?

• Doxycycline is taken orallywith or without food
• Doxycycline is taken once a dayor as a capsule whole
  • Take 1 capsule whole, preferably with a glass of water
  • Avoid close monitoring of your progress and side effects as they can lead to delayed or incomplete diagnosis of infection
• Take 2 capsules wholeor as a capsule. If you forget to take a capsule, wait 30 minutes to absorb fully or take it as a whole

Common Side Effects

Common side effects of Doxycycline+Lactic Acid Bacillus include:

• Nauseainform your doctor;
• Diarrhea
• Abdominal distension.

When should I not begin treatment?

Use Doxycycline+Lactic Acid Bacillus as directed by your doctor. It is strongly recommended to start treatment at the first signs of infection or disease, such as abdominal distension or diarrhoea, before initiating antibiotic therapy. Do not stop treatment at once, instead, consult your doctor if you forget to take a dose.

• Many people have a mild metallic taste in their mouth, but do not experience any of the common side effects listed here. If this happens, stop taking Doxycycline+Lactic Acid Bacillus and contact your doctor immediately.
• Some people feel better within a few days after taking Doxycycline+Lactic Acid Bacillus, however, there is a possibility of complications if you are hospitalized, especially if you forget to take a dose.
• Some people feel better than others after taking Doxycycline+Lactic Acid Bacillus, but it is important to contact your doctor if you feel unwell in any way.

When should I not start treatment?

Start treatment with the lowest dose and duration necessary. If you are not sure how to use Doxycycline+Lactic Acid Bacillus, you may consider switching to a different antibiotic or trying a probiotic instead of Doxycycline.

Product Name:Tetracycline HCl Capsules

ManufacturerSun Pharmaceutical Industries

Indication

Tetracycline HCl Capsules is used for treating infections caused by certain types of bacteria including skin, lung, ear, and sexually transmitted infections.

Side Effects

The most common side effects of Tetracycline HCl Capsules are diarrhea, loose stools, nausea, and vomiting.

Storage

Store in a cool and dry place, away from direct sunlight. Keep out of reach of children. Throw away after use.

Active Ingredients

Tetracycline HCl Capsules 100mg

Inactive Ingredients

Warnings

Always read the label and follow the directions for use. If symptoms persist, see a doctor.

Ingredients

Other than those, the following are inactive ingredients: colorant, colorin, colorin-hydrocodone, colorin-methyl, colorin-hydro, colorin-acetone.

Meyron, J. J., et al. A randomized, controlled trial of doxycycline as a therapeutic option for acne vulgaris. J Clin Invest. 1993, 154, 603-603.

1993, 154, 605-604.

1993, 154, 604-606.

Lane, S. L., et al. The efficacy of a combination therapy of a short-acting tetracycline-based antibiotic and a long-acting tetracycline-based antibiotic in patients with acne vulgaris. 1993, 154, 815-818.

1993, 154, 816-819.

1993, 154, 819-821.

Bax, A., et al. 1993, 154, 817-824.

1993, 154, 819-823.

Gossen, W.

Nasco, B., et al. 1993, 154, 823-822.

Ponthélle, S., et al. 1993, 154, 824-875.

Oterofacci, S., et al. 1993, 154, 823-826.

Tolstoy, M., et al. 1993, 154, 823-827.

1993, 154, 825-829.

Roeck, R., et al. 1993, 154, 829-832.

1993, 154, 830-832.